Reproduction Abstracts

Introduction: Steroidogenic factor 1 (SF-1) is essential for the development and function of steroidogenic tissues. Stable incorporation of SF-1 into embryonic stem cells has been reported to prime the cells for steroidogenesis.Materials and methods: In this study, we established SF1 transgenic mouse embryonic stem cell (SF1-mES cells) and analyzed expression of steroidogenesis-related genes and gonadal lineage-markers. We measured the secreted progester...